Later in the fall I noticed some leg tremors when she squatted. The following day he would not even drink water. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. Over time, I spent 7k to save here but to no avail. This will kill fleas and ticks. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Hello! Come to find out Akita blood platelets can explode in storage causing hi readings. Could this be caused by the med? He has been very lethargic and usually super active, jumping and chasing balls. We nurses him back into a happy healthy puppy and now this. We gave our 3.5 month old Aussie pup a dose of Simparica today (vet's prescription), and I did not see the warnings about giving it to dogs under 6 months. I just started my 80 pound pit on this same medication yesterday. It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . It is better but not gone. Heartworm medicine alone should be ok. Oh my god I'm so glad I found this group. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. Simparica Trio should be used with caution in dogs with a history of seizures. Like many of you, I was unsure about the cause. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. The leaflet inside at least needs to be changed to have the correct information on it. This time he is having seizures. Thank you to all of you posting and I hope all of your babies are doing well. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. I have had German Shepherds for 40 yrs. In the meantime i keep trying to give him ice and i am very worried that i have permanently harmed him. So if your dog actually has meningitis then that wouldn't be related to having given him Simparico but a separate matter altogether. I guarantee he will not take this trash again. We are going back to the Seresto collar next month. I am keeping a close eye on her and will take her to the vet if she hasnt improved by tonight. I don't know if the lump came from it or something else. So sorry to hear, and good for you in recognizing the problem! I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. Has anyone recently started simpatico trio on their fur baby and noticed any kidney problems? Since the weather was turning cold, I stopped giving her the Simparica until spring. gave this to my dog three different times. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) Sorry for the late replywe took our boy to the ER and after 2 days on fluids and a shot of Percorton, he was diagnosed with Addison's Disease. Two weeks after first simparica dose.parasites gone. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. I won't be letting this go and I'll be actively pursuing recourse from the manufacturer and vet in any way I can. They keep telling me that she would have been sick from the first pill, not just the 2nd. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. He is 11 so I attributed his slowing down on walks to aging but now he is recently limping and at times has some trouble with jumping up on the bed. Both my dogs have had runny eyes and were eating grass all summer. Thank you for this. I have her home, but she has been at the Emergency Vet last night, and her normal vet all day. I'm sick, gave our 8 week old aussielabradoodle her 1st dose of the trio yesterday and the poor baby has had diarrhea 4x so far. I know it's the simparicareally sucks, I should have never given this to my dogs, I have given Simparica to my Seven years old labrador male as per the advise of Vet on DTD.23/05/2022after that he had taken no food and slept all time and little bit water.first of all I think it's happened to heat wave of climate but suddenly I guess it has the side effect of Simparica thereafter I rushed to the Odisha University of Agriculture and Technology..after blood testthe vet. Started in February and within a couple of weeks ears started twitching. I feel so bad ,my 8weeks cockerspaniel hasnt been the same 24 hours of giving first dose of Simparica trio.My boy has been distressed with lethargic conditions,sleepy and peeing . It's 5:53pm and he's acting very lethargic. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Any other alternatives that are not harmful? Doubtful our dog will be given Simparica again. Is due for another tablet but I have been holding off. Also vets needs to tell the truth!!! During this period coincidentally I have noticed a change in his behaviour. Drinking water and peeing excessively. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. She's been fine since. The whole packet is going in the bin !! He had to be put to sleep and Im devastated. Even with what she has been through we have to wait until Dec 1st to see the Neurologist as there is only one in the State of Maine. Hi i have only had my pup for about a week and a half i took him to vet and asked what would be safe to use since my pup is only about 11weeks old and weighs 4pds (prob less today) i gave him this medicine last nite and wish i would have seen this post sooner Now i pray he makes it thru the night. Humans are another matter. I should have know it was a sign when he spat it out. We did skin scrape and they kept saying allergies. The company's thinking must be the profits outweigh the loses from any lawsuits lost its important to note that the law treats animals as property and the fix value of a dog is quite small and limited. So, again, tears in my heart, THANK YOU ALL SO MUCH for your generous information. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? Very "out of it". Other alternative drugs are likely to offer poorer protection. My French bulldog 2 years olds had a second attack in 3 days. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. I honestly think she had a reaction to the medication. Any tips on how to flush it from her system ? His motor skills have been affected and hes been losing weight even though he eats heartily. Stressing out now. 8 months of prednisone and around the clock nursing care at home saved her life. This is because it doesn't kill adult heartworms. My dog has had a previous back leg surgery. I was using the garlic tabs for the previous dog because the vet put him on Trifexis and he vomited like crazy. I was blaming the tremors in his back legs on the fact that he has had both ACLs repaired. Did the tremors ever stop? He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. He just isnt himself. I am continuing to recover at home and have to use an oxygen tank. I immediately filed a case number with Zoetis and informed my Vet as well as current Vet hospital he is being held at. I have a vet appointment tomorrow to figure it out. If anyone wants to write or call to complain to the company I have all the details. I will not be giving him simparica again. Will not be using this treatment again!!! Some reports showed the dogs could have simparica seizures. The FDA considers this level to be "very rare". This is so scary. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. not eating alor and wants me to rub her tummy constantly . It is really eye-opening to see everyone's experiences. After reading theses comments I started looking into SIMPARICA TRIO. I gave simparica trio to my 10-year-old Havanese. This is not at all his behavior. No appetite, not like Charlie. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. He was lethargic & laying in his crate alot . I gave them their 2nd dose, and 24 hours later, the Collie mix (Bella) was throwing up, lethargic, unsteady, drinking obsessively, panting, and could hardly walk. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions . I take her everywhere as I'm terrified of it happening and her dying, we were convinced she was dying. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. So far, the cost of diagnostic tests are about $700. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. These are classic neurological symptoms, exactly what our Pickles had before she passed. Different vet. The reaction lasted less than 12 hours. When he lays in the sun you can see the bumps under his skin. Never any issues with bravecto so we'll return to that medication. But today, after he ate dinner and drank water, it all came back up. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. His temp was high and white blood cells elevated. She has been diagnosed with thyroid problems and myocarditis. DO NOT give this poison to your pets. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Just a little nervous !! Please think these things through before subjecting your pet to internal insecticides. Bentlee has been fine for 12 + hours in the house while I was stuck at work and never a drop of anything in the house. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. Over two weeks later she still can not walk properly. Two days later, she is doing better, but not 100% yet. First month, the one threw up, same thing second month. Product Information: Simparica Trio (sarolaner, moxidectin, and pyrantel) Chewables are a safe monthly chewable for dogs that prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworms and . This happened the same to my dog.. how si going now with your pet? I will post an update 7 days later. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. Is the added expense worth the trouble to insure your beloved pet? I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. She had been on the Seresto collar and Tri-Heart for 8 years with no issues. They drew blood & took a fecal sample . The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The representative for the company says the half life is 16 days. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. They are also drinking more than normal. She went 11 days with no seizures and then had another gran mal. and you expect people to give this to their beloved pets? I'm so glad I found this forum, it confirmed my instincts that this drug is very harmful. It has been 20 days since I gave her the prescribed dose of Simparica. So from what I understand, your dog was on this for 6 months and got the serious symptoms after that? Are there any side effects to Simparica Trio? Vet says Simparica is not the reason for his condition, but he was totally fine prior to taking Simparica!! This dog was my partner and friend. They would clear up after a round of antibiotics but would return the next month. Product Details: Simparica Trio Chewables for dogs. He is very friendly with other people and pets and never had an issue in that regard. He is my first dog, he is 5yrs old now, and this is all new. The vet and company are in consultation. One has done great only notice that he is drinking a lot of water. So sorry! I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. She is absolutely miserable and we're hoping she makes it. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. I went to zoetis and Expressed my views and they said the FDA report meant nothing and it was in America. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). Tremors continued, on and off, for 2 hours. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. This is apparently not true and that's why the article never goes on to explain exactly why it only works on GABA receptors in fleas and ticks yet not affect the GABA receptors in your dog. Your pets condition worsens or does not improve with treatment, You have additional questions or concerns about the use of Simparica or Simparica Trio. Being in CT where Lyme disease is high it's a relief to have top shelf protection. Sarolaner (brand name Simparica) is used to treat and control flea and tick infestations in dogs. How is your puppy doing? It was 11:30 pm . Wednesday morning at 5am she awoke with bloody diarrhea and it turned into just blood. I had always thought how can something so lethal to fleas an ticks be safe to ingest? It was the first time she had taken Simparica. The next day she had diarrhea. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. Then things got progressively worse. Our golden retriever had his first seizure after taking Simparica Trio last October. It sounds as if she's been pinched while sleeping although nothing visible happened. Then suddenly dog has diarrhea and it lasted for several days. I feel like she's been an experiment to make others money. It's now March 23, he still has falls but not like at first. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). His neck felt swollen and he was panting heavily gasping for air. They kindly asked that we schedule an immediate check and diagnostic testing at our local vet. Im switching back to the old stuff. I had to put him laundry room for the night (no Carpet). I used to use revolution but they dont cover ticks as well. They got him to eat a little the next morning and sent him home. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. After about 2.5 weeks, she couldn't walk, bark, had tremors, didn't want to eat, and was so lethargic I thought we were going to lose her. She had the treatment yesterday and seemed ok. However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. She said to watch for drainage. Maybe? Then she lost control of her legs and couldn't walk or stand. I hate giving her these drugs in the first place but am always convinced it is the right thing to do. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. For 5 years I have resisted my veterinarians suggestions for oral flea meds. Did your dog pass away? My 15 yr old doodle wasnt given bravecto because of reviews. Vet gave her a shot which stopped it. What kind of supplements are you giving her? Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. Use topical or a collar if you are concerned. Thank you. Sarah thanks for your response! I hope we get to the bottom of it as this is not fun. She has been the healthiest, happiest dog. well my lola went into labor xmas day. Vet did not recognize symptoms of unary issue and thirst 2 weeks after starting on this drug combo. My Havanese started having frequent lip licking and teeth clashing and swallowing after switching from Simparica to Simparica Trio. If there are enough reports they may have to pull it off the market until further safety tests can be done. Took a dose of simparica trio.second rose in second month.dog is having tremors. She has been taking Trifexis for years with no problem. I gave him this medication last Thursday. Now his tail looks like a rat tail. Also feed bland diet- rice, ground beef, chicken, cottage cheese. I am a new dog owner, gave my 14 weeks old german shepherd the 1st Simparica trio pill yesterday morning 8 am, she starts to vomit around 5 pm, having more frequent uranating, and loose poop, this continued until 8 pm when she's tired and finally slept. Shes not the carefree setter she was prior to this medication. The doctor did blood work and gave him steroids and said to watch him carefully for the next few days. This is an eye opener for me! Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. He has trouble raising his leg to urinate. I recently switched my 3.5 year old German Shepard to simparica and about 2 weeks after his first dose he had two seizures in one night and has NEVER had them before. Im seeing an improvement in my dog, and am crossing fingers that this continues! I'm so angry this medication is on the market. Dr said either Simparica (best case scenario), GOLPP or brain tumor. #JusticeforCassie My thoughts and prayers are with you all as I go through the same thing with my beautiful Cassie girl. Head down, tail down, will stand in a corner and stare at the wall. In total we spend around $780 trying to control/stop the tremors & seizures. I switched all three of my dogs to simparica trio and ironically my one that is a simi feral h/w+ hound disappeared. My American Akita puppy took this pill on August 8th. All three drugs are pesticides that work by attacking the nervous system of the fleas and ticks, causing death. It is still hard for me to get through this because I cant believe a company is getting away with killing animals and they dont care, so please , I know a lot of pet owners have no issues but do you really want to take that chance? After reading all your entries, i'm thrilled i chose to take her off of it. He is very whinny and is drinking a lot of water. The third ingredient in Simparica Trio is. HELP!! I am a physical therapist, and acquired Sadie to serve as a Therapy Dog in our clinic. org to have this poison recalled. MONEY!!. My dog was HEALTHY and HAPPY prior to giving him this drug and literally days later he is struggling to recover. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. I have paid about $500 - $600 to heal the little King, but it's not working. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. This is terrible. Billy Boy is a 9 week old Daisy Dog. Related questions. The day I gave it to him, he was up all night just randomly crying and yelping like he was in pain. After being ingested by a dog, sarolaner is distributed throughout the body. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. I check this thread regularly and Im sooo grateful to all who wrote. Today she has fallen 2 or 3 times in the last 8 hours). The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. There is a possibility it isn't the cause, but it is the only reason I can find and it aligns with the stories of others. If you need to get rid of parasites, spot-on (the one by a German company is effective enough) will do the job and do it safely. Glad i held off on the free sample i was given! Advised her to put a big note on our account that she is never to have this again. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. The following day she got diarrhea and was extreemly quiet. I am so sorry to all of you and my heart goes out to you and your babies. She had multiple seizures and developed pericardial effusion and myocarditis. Gave Simparica yesterday and am suspect. 1 is pregnant I told the vet what can I give the pregnant yorkie she said sampirica sold me a 3 month supple for her. They must get some kind of monetary bonus for only selling Simparica. They both got similar issues and this was the only thing they both did. . Ticks are horrible here in Maine. Thanks all for sharing your experiences. My 11 year old mini Aussie has been taking Simparica 1.5 years. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Hi Charlene, can you elaborate on agitated swallowing? Good appetite and no digestive issues (never had that symptom). My vets comment was I would know if his symptoms were related if at time for next dose his symptoms were gone they are gone. The product can be purchased directly from your vet, from your vet's online pharmacy, or through an external online pharmacy with a valid prescription. The vet does not feel it is due to Simparica but i think it could be. Company asked us to do diagnostic testing at vet. I have noticed that recently he seems to stumble a little from time-to-time. Gave my 3 month old, 3 pound shih tzu simparica on Sunday night. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. Is there hope? They gave him IV glucose to raise his Potassium level. Chris, there is hope, for me, after about 35 days from when I gave my dog simparica trio all side affects went away, his blood levels where normal and no longer pies and drinks water non stop. My Labradoodle had extreme diarrhea last night. Now her dog is very sick and she has to take the dog to the vet every day in the past week. I took him to the energy vet in the morning, he couldnt find any cause for pain, only he yelped a bit on his neck, they had trouble getting him in, he was yanking his neck around as he is afraid of the vet since getting fixed. Im wondering if anyone else has seen these types of symptoms. She didn't make it to the next day and died overnight. The only thing the vet told me was that his ATL liver enzyme levels were just slightly high (170) and it wasn't a concern and we could just do another blood test at his next check-up. I have a happy healthy 14 yr old female bull terrier. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. We gave our one year old Simparica tonight and he started having trimmers that lasted on and off for about 30 minutes. This seemed like perfect treatment 3 in 1 but at what cost? Are their enough people to file a class action suit? The most common Simparica Trio for dogs side effects are; Lethargy Vomiting Diarrhea Loss of appetite Polydipsia Polyuria Hyperactivity Hyperactivity, polydipsia, and polyuria happened in very rare cases. So bad that the FDA made them put a huge warning now on the package. Its crazy to think they dont recover and can die in a few months. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). I assume it's getting out of his system. They said , he has a Autoimmune Hemolytic anemia . She was shaking like she was freezing. I am so mad at the vet and think we should file suit against this company. My dog is having the same issues. If not, we had some success with symptom management using Prednisone. And a bit more stumbling. I got my dog Josey up to let him out to pee. 38 results for "simparica trio for dogs" RESULTS. 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After a round of antibiotics but would return the next day and died overnight manufacturer the... Some reports showed the dogs could have Simparica seizures trimmers that lasted and... Multiple seizures and developed pericardial effusion and myocarditis he recommended this over topical. Any age, breed, or lactating dogs golden retriever had his first seizure after taking Simparica!!! Pound pit on this for 6 months and got the serious symptoms after that and may include: side. Some kind of monetary bonus for only selling Simparica few days he started having trimmers lasted! Over time, i spent 7k to save here but to no avail can something so to! It doesn & # x27 ; t kill adult heartworms, endoscopy ultrasound.